Patients with anti-IFN-γ autoantibodies have impaired IFN-γ signaling leading to severe disseminated infections with intracellular pathogens especially nontuberculous mycobacteria. High-titer neutralizing anti-IFN-γ autoantibodies affect the same pathway and cause a syndrome of disseminated nontuberculous mycobacterial and other opportunistic infections.2-5 These patients can have severe and progressive disease despite prolonged antimicrobial therapy which can result in… Continue reading Patients with anti-IFN-γ autoantibodies have impaired IFN-γ signaling leading to severe