Primary lymphomas of the central nervous system (PCNSLs) were investigated for

Primary lymphomas of the central nervous system (PCNSLs) were investigated for his or her capacity to perform further maturation steps. in one of three cases analyzed. This may indicate that ongoing somatic mutation, which is definitely seen in PCNSL frequently, could be because of sustained Help expression within a small percentage of cases which intraclonal… Continue reading Primary lymphomas of the central nervous system (PCNSLs) were investigated for

Transgenic mice carrying a 380-kb region of the human immunoglobulin (Ig)

Transgenic mice carrying a 380-kb region of the human immunoglobulin (Ig) light (L) chain locus in germline configuration were created. at the same developmental stage. This is further supported by the finding that in hybridomas expressing human Ig the endogenous L chain loci were in germline configuration. The presence of somatic hypermutation in the human… Continue reading Transgenic mice carrying a 380-kb region of the human immunoglobulin (Ig)

Background The aim of this study was to evaluate the efficacy

Background The aim of this study was to evaluate the efficacy of the p53-reactivating medicines RITA and nutlin3a in killing myeloma cells. of myeloma cells. The apoptosis that was induced by (R)-P7C3-Ome RITA was not related to the status of the cell lines or the del17p status of the primary samples (p = 0.52 and… Continue reading Background The aim of this study was to evaluate the efficacy