Transgenic mice carrying a 380-kb region of the human immunoglobulin (Ig) light (L) chain locus in germline configuration were created. at the same developmental stage. This is further supported by the finding that in hybridomas expressing human Ig the endogenous L chain loci were in germline configuration. The presence of somatic hypermutation in the human… Continue reading Transgenic mice carrying a 380-kb region of the human immunoglobulin (Ig)