Category: Kynurenine 3-Hydroxylase

Pleural tuberculosis (TB) as well as lymphatic TB constitutes more than

Pleural tuberculosis (TB) as well as lymphatic TB constitutes more than half of all extrapulmonary cases. CCR5 the primary receptor used by MCP-2/CCL8 is mostly expressed on pleural CD4+ T lymphocytes. Furthermore we found that infection with either Bacillus Calmette-GuĂ©rin (BCG) or H37Rv induced production of MCP-2/CCL8 at both transcriptional and protein level in Mouse…

The four serotypes of dengue virus (DENV-1 to -4) represent the

The four serotypes of dengue virus (DENV-1 to -4) represent the most prevalent mosquito-borne viral pathogens in humans. While there are several promising vaccine Nordihydroguaiaretic acid candidates in clinical trials approved vaccines or antivirals are not yet available. Here we describe the identification and characterization of a spiropyrazolopyridone as a novel inhibitor of DENV by…