Ack1 is a nonreceptor tyrosine kinase that participates in tumorigenesis cell migration and success. using the MHR as well as the cancer-associated E346K mutation prevents binding directly. Also mutation of an integral hydrophobic residue in the MHR (Phe820) stops the MHR-kinase conversation activates Ack1 and increases cell migration. Thus the cancer-associated mutation E346K appears to… Continue reading Ack1 is a nonreceptor tyrosine kinase that participates in tumorigenesis cell