Introduction Direct damage reversal (DDR) mechanisms correct DNA lesions without trimming the DNA backbone. here the O6-alkylguanine DNA alkyltransferase (AGT) is usually a highly-conserved protein responsible for direct repair of alkylated guanine and to a lesser degree thymine bases [3 5 In addition to protecting the genome under normal conditions AGT has also recently become… Continue reading Introduction Direct damage reversal (DDR) mechanisms correct DNA lesions without trimming