Mutations leading to protein misfolding and proteolysis are associated with many genetic diseases. 2008; Roth 2008). On the other hand degradation of misfolded proteins as MK-2894 the result of point mutations can also be detrimental and lead to loss of function diseases such as cystic fibrosis and phenylketonuria (Cheng 1990; Lichter-Konecki 1988). In this case… Continue reading Mutations leading to protein misfolding and proteolysis are associated with many