History Myocardial fibrosis is a hallmark of hypertrophic cardiomyopathy and a proposed substrate for arrhythmias and heart failure. not have mutations. Levels of serum C-terminal propeptide of type I procollagen (PICP) were significantly higher in mutation carriers without left ventricular hypertrophy and in subjects with overt hypertrophic cardiomyopathy than in controls (31% and 69% higher… Continue reading History Myocardial fibrosis is a hallmark of hypertrophic cardiomyopathy and a
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Focal adhesion kinase (FAK) is normally a ubiquitously portrayed cytoplasmic tyrosine
Focal adhesion kinase (FAK) is normally a ubiquitously portrayed cytoplasmic tyrosine kinase strongly turned on by integrins and neurohumoral factors. and cFos manifestation induced by adrenergic agonists and biomechanical tension. Furthermore we discovered that continual problem of mice with myocyte-restricted FAK inactivation qualified prospects to improved cardiac fibrosis and cardiac dysfunction compared to challenged hereditary… Continue reading Focal adhesion kinase (FAK) is normally a ubiquitously portrayed cytoplasmic tyrosine