Uncontrolled inflammation is one of the leading causes of kidney failure. detectors mediators and effectors of swelling in the kidney via P2Y14. Introduction Kidney failure is almost usually associated with uncontrolled swelling [1 2 A link between renal swelling and signaling via purinergic receptors has been established but very little is currently known concerning the… Continue reading Uncontrolled inflammation is one of the leading causes of kidney failure.
Tag: NNC 55-0396
Intramembrane proteases catalyze the signal-generating step of various cell signaling pathways
Intramembrane proteases catalyze the signal-generating step of various cell signaling pathways and continue to be implicated in diseases ranging from malaria illness to Parkinsonian neurodegeneration1-3. deleting the amino-terminal EF-hands triggered proteolysis prematurely while residues in cytoplasmic loops linking distal transmembrane segments mediated calcium activation. Rhomboid regulation was not orchestrated by either dimerization or substrate relationships.… Continue reading Intramembrane proteases catalyze the signal-generating step of various cell signaling pathways