The 26S proteasome a central enzyme for ubiquitin-dependent proteolysis is an extremely complex structure comprising 33 distinct subunits. pathways exist in cells but the contribution of the chaperone-dependent pathway remains unclear. To elucidate its biological significance in mammals we generated PAC1 conditional knockout mice. PAC1-null mice exhibited early embryonic lethality demonstrating that PAC1 is essential… Continue reading The 26S proteasome a central enzyme for ubiquitin-dependent proteolysis is an