Appropriate supply of deoxyribonucleotides from the ribonucleotide reductase (RNR) complex is essential for DNA replication and repair. Spd1. DNA-replication stress appears to allow Caf1 to interact with Suc22 resulting in release of the nucleoplasmic Spd1-Suc22 assembly. Taken collectively these results suggest a novel function of Caf1 as a key regulator in the stress-induced RNR activation.… Continue reading Appropriate supply of deoxyribonucleotides from the ribonucleotide reductase (RNR) complex is