Transforming growth issue-β (TGF-β) has an essential role in the generation of inducible regulatory T (iTreg) and T helper 17 (Th17) cells. (IL-2) a known inhibitor of Th17 differentiation. Remarkably TRAF6-deficient cells generate normal numbers of Foxp3-expressing cells in iTreg differentiation conditions where exogenous IL-2 is supplied. These findings show an unexpected role for the… Continue reading Transforming growth issue-β (TGF-β) has an essential role in the generation