Malignant pleural mesothelioma (MPM) originates generally in most of the cases from chronic inflammation of the mesothelium due to exposure to asbestos fibers. blockade by chloroquine in combination with the dual PI3K/mTOR inhibitors significantly induced caspase-independent Losmapimod cell death involving RIP1 in the sensitive cell line SPC212. Cell death in the resistant cell line Mero-82… Continue reading Malignant pleural mesothelioma (MPM) originates generally in most of the cases