The translesion DNA synthesis (TLS) polymerase REV1 is implicated within the bypass from the irreparable DNA harm such as for example interstrand crosslinks (ICLs). DDR pathway. Notably site dissection analysis shows a C-terminal site but not the average person ubiquitin binding motifs of REV1 is essential for the binding of REV1 to MMC-damaged chromatin as… Continue reading The translesion DNA synthesis (TLS) polymerase REV1 is implicated within the