To determine if saquinavir mesylate (saquinavir) is a substrate of individual multidrug resistance-associated proteins 1 (hMRP1 [ABCC1]) or hMRP2 (cMOAT or ABCC2) MDCKII cells that overexpress possibly hMRP1 (MDCKII-MRP1) or hMRP2 (MDCKII-MRP2) were used to research saquinavir’s cytotoxicity and transportation in comparison to those of control MDCKII wild-type (MDCKII/wt) cells. dosage [LD50] = 10.5 μM)… Continue reading To determine if saquinavir mesylate (saquinavir) is a substrate of individual