Among the many macromolecular machines involved in eukaryotic gene expression the spliceosome remains one of the most challenging for Tacalcitol structural biologists. Together these tools are rapidly changing our structural appreciation of this amazingly dynamic machine. Introduction In all organisms gene expression requires coordinate action of multiple macromolecular machines many with multi-megadalton (MDa) molecular weights.… Continue reading Among the many macromolecular machines involved in eukaryotic gene expression the