The pregnane x receptor (PXR) is a nuclear receptor transcription factor regulating drug-metabolizing enzymes and transporters that facilitate xenobiotic and endobiotic cleansing. substantially lower in PXR-null than wild type mouse livers after LPS/GalN treatment. Autophagy is also involved in LPS/GalN-induced liver injury. Lack of PXR resulted in a significant reduction of LC3B-I -II as well… Continue reading The pregnane x receptor (PXR) is a nuclear receptor transcription factor