Several ellagitannins inhibited the activity of protein phosphatase-1 (PP1) and -2?A (PP2A) catalytic subunits (PP1c and PP2Ac) with preferential suppression of PP1c over PP2Ac. PGG or EGCG by NMR saturation transfer difference suggested that these molecules, at least in part, exert inhibitory potency on BMS-650032 supplier PP1c via interacting with the hydrophobic substrate-binding groove. Both… Continue reading Several ellagitannins inhibited the activity of protein phosphatase-1 (PP1) and -2?A