Aims/Hypothesis There is controversy with respect to molecular characteristics of insulin analogues. than IR binding affinity whereas detemir displayed an IGF-1R:IR binding ratio of ≤1. Ligands with high relative IGF-1R affinity also had high affinity for IR/IGF-1R hybrid receptors. In general the relative binding affinities of the analogues were reflected in their ability to phosphorylate… Continue reading Aims/Hypothesis There is controversy with respect to molecular characteristics of insulin