The phosphatidylinositol 3-kinase (PI3K) signaling pathway is deregulated in lots of human illnesses including cancer diabetes obesity and autoimmunity. for extreme care in examining PI3K activity because anti-p85 immunoprecipitations may contain both p85:p110-PI3K and p85:PTEN-phosphatase enzymes and therefore measure net PI3K activity. We recognize the N-terminal SH3-BH area of p85α absent in small p55α and… Continue reading The phosphatidylinositol 3-kinase (PI3K) signaling pathway is deregulated in lots of