Activation of the oncogenic potential of the MEK kinase TPL-2 (Cot) requires deletion of its C terminus. in addition to its role as a precursor for p50 and cytoplasmic inhibitor of NF-B, p105 is usually a negative regulator of TPL-2. Insensitivity of C-terminally truncated TPL-2 to this regulatory mechanism is likely to contribute to its… Continue reading Activation of the oncogenic potential of the MEK kinase TPL-2 (Cot)