Tag: order LY2228820

Supplementary MaterialsFigures & Furniture: Fig. regulator (CFTR) that result in reduced

Supplementary MaterialsFigures & Furniture: Fig. regulator (CFTR) that result in reduced anion conductance at the apical membrane of secretory epithelia. Treatment of CF patients transporting the G551D gating mutation with the potentiator VX-770 (ivacaftor) largely restores channel activity and has shown substantial clinical benefit. However, most CF patients carry the F508 mutation, which impairs CFTR…