The restriction factor SAMHD1 limits HIV-1 replication in non-cycling cells. L2 and SAMHD1 form a molecular complex that is partially dependent on the presence of DCAF1 and results in SAMHD1 degradation inside a proteasome- and DCAF1-dependent manner. Therefore Cyclin L2-mediated control of SAMHD1 levels in macrophages helps HIV-1 replication. Intro HIV-2 and its counterpart Simian… Continue reading The restriction factor SAMHD1 limits HIV-1 replication in non-cycling cells. L2