Prostate malignancy stem-like cells (PCSCs) are being intensely investigated largely owing to their efforts towards prostate tumorigenesis, however, our understanding of PCSC biology, including their critical pathways, remains incompletely understood. or ERK2 resulted in a strong reduction in PCSC propagation. Collectively, the present study provides evidence that EGFR signaling promotes PCSC self-renewal, in part, by… Continue reading Prostate malignancy stem-like cells (PCSCs) are being intensely investigated largely owing
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We have previously discovered the naturally occurring antitussive alkaloid noscapine as
We have previously discovered the naturally occurring antitussive alkaloid noscapine as a tubulin-binding agent that attenuates microtubule dynamics and arrests mammalian cells at mitosis via activation of the c-Jun NH2-terminal kinase pathway. with wild-type p53 status. This increase in p53 is associated with an increased apoptotic BAX/Bcl-2 ratio consistent with increased sensitivity of these cells… Continue reading We have previously discovered the naturally occurring antitussive alkaloid noscapine as