Background Anakinra may be the first interleukin-1 inhibitor to be used

Background Anakinra may be the first interleukin-1 inhibitor to be used in clinical practice, and recent evidence showed that interleukin-1 plays a pivotal role in the pathogenesis of adult-onset Still disease (AoSD). Results Of the 273 articles that were identified, 265 were excluded. Eight studies were eligible for inclusion. The overall remission rate and total… Continue reading Background Anakinra may be the first interleukin-1 inhibitor to be used

Electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry coupled with

Electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry coupled with capillary reverse-phase liquid chromatography was used to characterize intact proteins from the large subunit of the yeast ribosome. be an important complement to other approaches for defining protein modifications and their changes resulting from physiological processes or environmental perturbations. Mass spectrometry has evolved into… Continue reading Electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry coupled with

Alternative promoter usage is typically associated with mRNAs with differing first

Alternative promoter usage is typically associated with mRNAs with differing first exons that contain or consist entirely of a 5′ untranslated region. murine testis. Using analysis we identified a putative steroidogenic factor-1 (SF-1) response element that was unique to the Bcrp1 E1U alternative promoter. Overexpression of SF-1 in murine TM4 Sertoli cells enhanced E1U mRNA… Continue reading Alternative promoter usage is typically associated with mRNAs with differing first