Aggregation of the high-affinity IgE receptor (FcRI) initiates a cascade of signaling events leading to release of preformed inflammatory and allergy mediators and synthesis and secretion of cytokines and other compounds. glycosphingolipid-enriched membrane microdomains (PAG), and growth factor receptor-bound protein 2 (Grb2)-binding adaptor protein, transmembrane (GAPT)]; engagement of four of them (LAT, NTAL, LAX, and… Continue reading Aggregation of the high-affinity IgE receptor (FcRI) initiates a cascade of