The pseudorabies virus (PRV) Us2 protein binds towards the extracellular-regulated kinase (ERK) and inhibits the activation LAQ824 of ERK nuclear targets by sequestering cytoplasmic ERK on cellular membranes. substrates. ERK carrying mutations within the MEK binding region maintained the ability to bind Us2 whereas ERK carrying mutations within the CD domain did not. Furthermore the… Continue reading The pseudorabies virus (PRV) Us2 protein binds towards the extracellular-regulated kinase