Background Haptoglobin genotypes, and interleukin-6 and -8 participate in the pathophysiology of sickle cell anemia. hematopoiesis.9 Several studies have shown that this levels of cytokines in patients with SCA, even in steady state, are elevated.10, 11, 12, 13 In individuals with SCA, pro-inflammatory cytokines such as IL-1, IL-6, IL-8 and tumor necrosis factor alpha (TNF-)… Continue reading Background Haptoglobin genotypes, and interleukin-6 and -8 participate in the pathophysiology