Supplementary MaterialsFigure S1 41419_2019_1919_MOESM1_ESM. in the mouse model. Finally, we demonstrated that p53 manifestation could be governed with the ATF6/XBP1/CHOP axis to market the introduction of CP. We as a result conclude that ATF6 signalling regulates CP development by modulating pancreatic acinar cell apoptosis, which gives a target for ER stress-based treatment and diagnosis of… Continue reading Supplementary MaterialsFigure S1 41419_2019_1919_MOESM1_ESM. in the mouse model. Finally, we demonstrated
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Supplementary Materials Supporting Information supp_107_12_5551__index. in thymic cellularity was observed in
Supplementary Materials Supporting Information supp_107_12_5551__index. in thymic cellularity was observed in the dCK KO mice relative to wild-type littermates. Lymphocyte figures in the dCK KO mice were 5- to 13-fold below normal values. The severe impact of dCK inactivation on lymphopoiesis was unexpected given that nucleoside salvage has been thought to play a limited, “fine-tuning”… Continue reading Supplementary Materials Supporting Information supp_107_12_5551__index. in thymic cellularity was observed in