Background Down regulation of genes coding for nucleoside transporters and drug metabolism in charge of uptake and metabolic activation from the nucleoside gemcitabine is related to acquired tumor resistance from this agent. Our outcomes demonstrate that obtained gemcitabine level of resistance is definitely connected with DNA promoter methylation-independent and gene down-regulation and hyper-expression of G9A… Continue reading Background Down regulation of genes coding for nucleoside transporters and drug