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Supplementary Materials Appendix EMMM-10-e8536-s001. and protein\based inhibitors, we demonstrated that PGE

Supplementary Materials Appendix EMMM-10-e8536-s001. and protein\based inhibitors, we demonstrated that PGE 2 regulates MEF2 via the EP 3 receptor, the subunit of Gi/o protein and two concomitantly activated downstream pathways. The first consists of Tiam1, Rac1, and its effector p21\activated kinase 2, the second of proteins kinase D. Both pathways converge on and inactivate histone…