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Although both pathological hallmarks of Alzheimer’s disease (AD), senile plaques composed

Although both pathological hallmarks of Alzheimer’s disease (AD), senile plaques composed of amyloid- (A) peptides and neurofibrillary tangles (NFTs) consisting of hyperphosphorylated tau, have been studied extensively in postmortem AD and relevant animal and cellular models, the pathogenesis of AD remains unknown, particularly in the early stages of the disease where therapies presumably would be…