THF-diols (9,12-oxy-10,13-dihydroxyoctadecanoic and 10,13-oxy-9,12-dihydroxyoctadecanoic acids) are endocrine disrupters in rats and mitogens in breast cancer cells. sites and blocked sexual behavior in male and female rats [4] at a very low dose (~0.30 mg/kg body weight/day). The second mitogenic HPLC peak of mitogenic activity was subsequently identified as 9,10-dihydroxy-12-octadecenoic acid (leukotoxin diol; LTX-diol), a well-known… Continue reading THF-diols (9,12-oxy-10,13-dihydroxyoctadecanoic and 10,13-oxy-9,12-dihydroxyoctadecanoic acids) are endocrine disrupters in rats and