Cardiac fibrosis contributes significantly to the phenotype of the chronically failing heart. than healthy control subjects (< 0.01). We found that cardiomyocytes constitutively secrete SDF-1 which is definitely significantly up-regulated by angiotensin II. SDF-1 was shown to raises cardiac fibroblast migration by 59% (< 0.05). Taken collectively our data suggest that recruitment of bone marrow-derived… Continue reading Cardiac fibrosis contributes significantly to the phenotype of the chronically failing