Category: M1 Receptors

Background and purpose: Nitric oxide (NO) controls numerous physiological processes by

Background and purpose: Nitric oxide (NO) controls numerous physiological processes by activation of its receptor guanylyl cyclase (sGC) leading to the accumulation of 3′-5′ cyclic guanosine monophosphate (cGMP). of cGMP and inactivation of NO were both inhibited by the CaM antagonists ruling out increased lack of cGMP or NO as explanations. Rather calmidazolium straight inhibited…

Proteasome inhibitors can resensitize cells that are resistant to tumors necrosis

Proteasome inhibitors can resensitize cells that are resistant to tumors necrosis factor-related apoptotic-inducing ligand (TRAIL)-mediated apoptosis. treatment with bortezomib or MG132 resulted in an increase of death receptor (DR) 5 and Bik at protein levels but experienced no effects on protein levels of DR4 Bax Bak Bcl-2 Bcl-XL or Flice-inhibitory protein (FLIP). Moreover c-Jun N-terminal…