Category: Lipoprotein Lipase

Background and purpose: Inhibition of HERG channels prolongs the ventricular action

Background and purpose: Inhibition of HERG channels prolongs the ventricular action potential and the QT interval with the risk of arrhythmias and sudden cardiac death. block was observed for amiodarone cisapride droperidol and haloperidol (group 1) whereas bepridil domperidone E-4031 and terfenadine (group 2) induced related pulse-dependent block whatsoever frequencies. With the group 1 compounds…