Category: K+ Channels

The PI3K/AKT/mTOR pathway is generally activated in head and neck squamous

The PI3K/AKT/mTOR pathway is generally activated in head and neck squamous cell carcinoma (HNSCC) but pathway inhibition has variable efficacy. inhibitors using a diverse selection of goals and by determining mechanisms of level of resistance and potential mixture therapies. We utilized reverse-phase proteins arrays (RPPA) to concurrently evaluate appearance of 195 protein; single-nucleotide polymorphism array…

Recent studies have shown the fact that novel dopamine (DA) D3

Recent studies have shown the fact that novel dopamine (DA) D3 receptor antagonists SB-277011A and NGB 2904 inhibit cocaine- and/or stress-induced reinstatement of drug-seeking behavior. reinstatement of drug-seeking. We discovered that cocaine-associated cues evoked solid reinstatement of lever-pressing. Acute intraperitoneal (i.p.) administration of SB-277011A (6 12 or 24 mg/kg) created a dose-dependent inhibition of cue-induced…