The Rvb1-Rvb2-Tah1-Pih1 (R2TP) organic is a co-chaperone complex that works together with HSP90 in the activation and assembly of several macromolecular complexes, including RNA polymerase II (Pol II) and complexes of the phosphatidylinositol-3-kinase-like family of kinases (PIKKs), such as mTORC1 and ATR/ATRIP. structural characterization of R2TP offers exposed an alpha-helical website in the C-terminus of… Continue reading The Rvb1-Rvb2-Tah1-Pih1 (R2TP) organic is a co-chaperone complex that works together with HSP90 in the activation and assembly of several macromolecular complexes, including RNA polymerase II (Pol II) and complexes of the phosphatidylinositol-3-kinase-like family of kinases (PIKKs), such as mTORC1 and ATR/ATRIP