Category: Calcium Signaling

Focal adhesion kinase (FAK) controls adhesion-dependent cell motility survival and proliferation.

Focal adhesion kinase (FAK) controls adhesion-dependent cell motility survival and proliferation. motif on FERM that regulates co-activation and nuclear localization. FAK dimerization requires local enrichment which occurs specifically at focal adhesions. Paxillin plays a dual role by recruiting FAK to focal adhesions and by reinforcing the FAT:FERM interaction. Our results provide a structural and mechanistic…

The miR-17-92 cluster of microRNAs is elevated in colorectal cancer and

The miR-17-92 cluster of microRNAs is elevated in colorectal cancer and has a causative role in cancer development. tumour progression. In colorectal cancer samples and corresponding normal colorectal mucosa miR-18a displayed lower overall expression than other miR-17-92 cluster members. miR-18a was shown to have an opposing role to other miR-17-92 cluster members in particular the…

The endoplasmic reticulum (ER) is a cellular organelle in charge of

The endoplasmic reticulum (ER) is a cellular organelle in charge of multiple important cellular functions including the biosynthesis and folding of newly synthesized proteins destined for secretion such as insulin. conditions such as (Inositol requiring enzyme 1) and ATF6 (activating transcription element 6). Under unstressed conditions these three proteins are held from the abundant ER…

Background Latexin also called endogenous carboxypeptidase inhibitor (CPI) has been found

Background Latexin also called endogenous carboxypeptidase inhibitor (CPI) has been found to inhibit mouse stem cell populations and lymphoma cell proliferation demonstrating its potential role as a tumor suppressor. transfected with LXN gene and BGC823 cells (latexin positive) stably transfected NMS-873 with antisense LXN gene were established for anchorage-dependent colony formation assay and tumorigenesis assay…

We performed a randomized controlled trial in 30 HIV-infected individuals to

We performed a randomized controlled trial in 30 HIV-infected individuals to either continue tenofovir/emtricitabine/efavirenz (Continuation Group) or change to tenofovir/emtricitabine/raltegravir (Change Group) for 24 weeks. the usage of potent antiretroviral therapies (Artwork) coronary disease (CVD) provides emerged as a respected reason behind morbidity and mortality.1 One mechanism where HIV infection or its therapies can lead…

Vesosomes – hierarchical assemblies consisting of membrane-bound vesicles of various scales

Vesosomes – hierarchical assemblies consisting of membrane-bound vesicles of various scales – are potentially powerful models of cellular compartmentalization. When a water-in-oil droplet passed through a second lipid monolayer formed in the continuous flow microcentrifuge a bilayer-encapsulated vesosome was created which contained all of the contents of the aqueous phase encapsulated within the vesosome. Encapsulation…

Background Although the relationship between obsessive compulsive disorder (OCD) and obsessive

Background Although the relationship between obsessive compulsive disorder (OCD) and obsessive compulsive character disorder (OCPD) has long been debated clinical samples of OCD (without OCPD) and OCPD (without OCD) have never been systematically compared. assessments and a validated intertemporal choice task that measures capacity to forego small immediate rewards for larger delayed rewards. Results OCD…