History Reproduction in pigs is one of the most economically important

History Reproduction in pigs is one of the most economically important traits. genes were sorted by the degree Abiraterone of relevance with the reproduction topics and were visualized in a gene’s co-occurrence network Rabbit Polyclonal to iNOS (phospho-Tyr151). where two genes were connected if they were co-cited in a PubMed abstract. The ‘hub’ genes which had more ‘neighbors’ were thought to be have more important functions and could be identified by the user in their web browser. In addition ReCGiP provided integrated GO annotation OMIM and biological pathway information collected from the Internet. Both pig and human gene information can be found in the database which is now available. Conclusions ReCGiP is a unique database providing information on reproduction related genes for pig. It can be used in the area of the molecular genetics the genetic linkage map and the breeding of the pig and other livestock. Moreover it can be used as a reference for human reproduction research. Background Pork is the major red meat source worldwide which contributes to forty-three percent of the world’s red meat consumed [1]. Good pork production requires that pigs have high levels of reproduction meat quality carcass merit disease resistance and survivability [1]. The improvement of reproductive performance in pigs has attracted Abiraterone great attentions of researchers because moderate increases in litter size will lead to great economic benefits [2]. However traditional selection methods based on estimated breeding value are expensive laborious and time consuming. Moreover it results in only low genetic gain. This is why it is important to understand the genetic basis of traits affecting reproduction and to use the marker assisted selection method (MAS) in order to achieve more straightforward results. At present there are two methods to identify genetic markers: the genome scans approaches and the candidate gene approach. The candidate gene approach is the most direct method of testing association between a gene and a phenotype [3] and can be utilized in any populations with a well-known pedigree in which phenotypes can be measured [4]. The candidate gene approach has been proved extremely powerful for studying the genetic architecture of reproduction traits. For example with this approach Rothschild et al. [5] demonstrated that there was a significant correlation between the estrogen receptor gene (ESR) and litter size. In principle candidate gene approach can be applied if a gene has a potential influence on a phenotypical trait (physiological candidate) located in a narrowed QTL region (positional candidate) or has an influence on the Abiraterone phenotypical trait in other species (comparative applicant) [6]. Nevertheless there have been limited positional applicants linked to pig’s duplication traits up to now. Thus applicant genes for duplication attributes in pig are physiological or comparative applicant mainly. Most of analysts choose applicant genes by intensive literature reading. Digital literature is currently developing in companion using the development of the life span science rapidly. At the same time increasingly more directories appear. The data source of PubMed biomedical books offers over 19 470 0 entries and embraces nearly every field of existence sciences. Every whole season more than 600 0 literatures are published. It isn’t simple for a researcher of a specific area to learn all the documents in his field aside from the books in the related field. As about the pig we still do not get the entire map of its genome and our understanding of reproductive applicant genes is bound. The directories for genome karyotype genome mapping EST SNP and QTL of pig have Abiraterone already been established [7] nevertheless there’s a web page list catalog of porcine genes appealing in endocrinology and duplication [8]. There continues to be no data source bearing up-to-date applicant genes for duplication attributes of pig. Predicated on hereditary similarity between human being and pig as well as the extensive studies on human being reproductive hereditary mechanism we developed ReCGiP (Database of Reproduction Candidate Genes in Pigs based on bibliomics). According to comparative genomics studies human candidate reproduction genes can be used as reference counterpart of that in pigs. By mining and analyzing the biomedical literature database using natural language.