Objectives To assess the level of sensitivity and specificity of self-reported

Objectives To assess the level of sensitivity and specificity of self-reported osteoporosis weighed against dual energy X-ray absorptiometry (DXA) defined osteoporosis also to describe medicine use among individuals with the problem. aged 50 years along with DXA-defined osteoporosis had been acquiring bisphosphonates ≥. Conclusions The level of sensitivity of self-reporting to recognize osteoporosis can be low. Anti-osteoporotic medicines are an important part of osteoporosis treatment but opportunities to use appropriate medications were missed and inappropriate medications were used. dual energy X-ray absorptiometry (DXA)–diagnosed osteoporosis and osteopenia in patients aged ≥ 50 years (CI -confidence interval) The use of self-reported osteoporosis in epidemio-logical or population studies as a screening tool for DXA-diagnosed osteopenia or osteoporosis was assessed and the sensitivity specificity positive and negative predictive values were calculated. The sensitivity was 22.7% specificity 94.4% positive predictive value 47.1% and negative predictive value 84.8%. This shows that the positive predictive value of having low BMD on DXA in people who self-report that they have osteoporosis is poor (47.1%) but the proportion of people with no self-reported osteoporosis who have normal DXA results is high (specificity of 94.4%). In terms of medication use of the respondents who self-reported that they had osteoporosis 43.9% (n = 50) used oral bisphosphonates and a small proportion of respondents who stated that they did not have osteo-porosis also took bisphosphonates (0.4%; n = 13) indicating a lack of understanding as to why they were taking particular medications. Of those who self-reported that they had osteoporosis the most frequently used bisphosphonate was alendronate Etomoxir (72.2%; n = 36). There were also three respondents (2.4%) who stated that Etomoxir they Etomoxir had osteoporosis and were taking raloxifene. No other bone specific drugs such as zolendronate or strontium ranelate (available on the PBS since 2009 and 2007 respectively) were used. Finally there were nine respondents (7.8%) who said they had been told that they had osteoporosis and took a form of hormone replacement therapy (HRT). Of the participants with DXA-defined osteoporosis or osteopenia 16.1% (n = 21) and 13.3% (n = 6) were taking bisphosphonates respectively as were 3.1% (n = 27) of those with a normal DXA scan. However among all respondents who stated that they had osteoporosis and were taking a bisphosphonate only 12.1% (n = 6) also took both calcium and vitamin D (including calcitriol). Of those with osteoporosis Etomoxir and -taking a bisphosphonate 31.4% (n = 16) were also taking proton pump inhibitors. Of all participants aged ≥ 50 years 2.9% (n = 38; 95%?CI 2.1 to 3.9) were on oral steroids and eight of these (21.4% (95% CI 10.6 to 38.5)) were also taking bisphosphonates. Of those on steroids 0.8% (n = 1) and 22.2% (n = 6) had DXA-defined osteoporosis and osteopenia respectively and 37.7% (n = 2) of those who had took -steroids and had undertaken a DXA scan were also taking bisphosphonates. Among respondents who had a fracture due to a fall from a standing up height or much less within the last five years 16.8% (n = 33; 95 CI 11.9 to 23.2) have been told by way of Etomoxir a doctor that that they had osteoporosis. Of the respondents 59 (n = 9; 95% CI 41.8 to 74.2) were on bisphos-phonates and 12.0% (n = 4; 95% CI 4.6 to 27.6) were currently on benzodiazepines. When contemplating those aged ≥ 50 years just 7.8% (n = 7) of these who had a fall had a bone relative density within the osteoporotic range. Of these acquiring benzodiazepines 3.8% (n = 2) and 14.0% (n = 8) respectively had DXA-defined osteoporosis or osteopenia. Dialogue Our TM4SF20 results display that self-reported osteoporosis can be badly predictive of DXA-diagnosed osteopenia or osteoporosis with a confident predictive worth no much better than opportunity at 47%. Of these individuals who got stated that that they had been diagnosed by their doctor as having osteoporosis 9 got DXA-defined osteoporosis further recommending that self-reported clinically diagnosed osteoporosis will probably lack accuracy inside a human population study like this. Furthermore our outcomes also display that despite the fact that medicine is an essential section of osteoporosis treatment and fracture avoidance for all those whose doctor got told them that they had osteoporosis and the ones who got suffered a minor.