Supplementary MaterialsSupplementary Data. length is usually telomerase dependent without TMP 269 impacting telomerase biogenesis or targeting of the enzyme to telomeres. Instead, RTEL1 depletion led to a decrease in both G-overhang content TMP 269 and POT1 association with telomeres with limited telomere uncapping. Strikingly, overexpression of POT1 restored telomere length but not the overhang, demonstrating… Continue reading Supplementary MaterialsSupplementary Data. length is usually telomerase dependent without TMP