Chaperone-mediated autophagy (CMA) selectively degrades a subset of cytosolic proteins in

Chaperone-mediated autophagy (CMA) selectively degrades a subset of cytosolic proteins in lysosomes. concurrent with elevated degrees of cytosolic adipose triglyceride lipase (ATGL) and macroautophagy protein on LD. CMA blockage both in cultured cells and mouse liver organ or appearance of CMA-resistant PLINs result in decreased association of ATGL and macrolipophagy-related proteins with LD and the… Continue reading Chaperone-mediated autophagy (CMA) selectively degrades a subset of cytosolic proteins in

Amyloid beta (Aβ) binding alcohol dehydrogenase (ABAD) is a cellular cofactor

Amyloid beta (Aβ) binding alcohol dehydrogenase (ABAD) is a cellular cofactor for promoting (Aβ)-mediated mitochondrial and neuronal dysfunction and cognitive decline in transgenic Alzheimer’s disease (AD) mouse models. levels suggesting protective mitochondrial function effects of these synthesized compounds. Thus these compounds are potential candidates for further pharmacologic development to target ABAD to improve mitochondrial function.… Continue reading Amyloid beta (Aβ) binding alcohol dehydrogenase (ABAD) is a cellular cofactor