Supplementary MaterialsAdditional file 1 Table S1. by abnormalities of chromosome 7, including large deletions or chromosomal loss. A variety of studies suggest that decreased expression of the em EZH2 /em gene located at 7q36.1 is critical in disease pathogenesis. This histone methyltransferase has been implicated in transcriptional repression through modifying histone H3 on lysine 27… Continue reading Supplementary MaterialsAdditional file 1 Table S1. by abnormalities of chromosome 7,