Objective A dramatic loss of aggrecan proteoglycan from cartilage is associated with osteoarthritis. vesicles. Following trypsinization, the intracellular build up of both epitopes was clearly visible. IL-1 treatment improved extracellular as well as intracellular ITEGE epitope build up. Once internalized, the ITEGE neoepitope became localized within the nucleus and displayed little colocalization with HA, DIPEN,… Continue reading Objective A dramatic loss of aggrecan proteoglycan from cartilage is associated
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Chk2 is a checkpoint kinase involved in the ataxia telangiectasia mutated
Chk2 is a checkpoint kinase involved in the ataxia telangiectasia mutated pathway which is activated by genomic instability and DNA damage leading to either cell death (apoptosis) or cell cycle arrest. for cell viability using a standard MTS assay (in two different ovarian cell lines OVCAR-4 and OVCAR-8 that communicate high levels of Chk2 (Fig.… Continue reading Chk2 is a checkpoint kinase involved in the ataxia telangiectasia mutated