Endoplasmic reticulum (ER) stress activates the unfolded protein response and its own dysfunction is associated with multiple diseases. chemical substance space of inhibitors and validate the inhibitor binding site. These PF-04447943 research lay the building blocks for understanding both biochemical and mobile features of IRE1α using little molecule inhibitors and recommend new strategies for inhibitor… Continue reading Endoplasmic reticulum (ER) stress activates the unfolded protein response and its