Prion-like RNA binding proteins (RBPs) such as for example TDP43 and FUS are largely soluble in the nucleus but form solid pathological aggregates when mislocalized towards the cytoplasm. which high RNA concentrations maintain RBPs soluble. Adjustments in RNA levels or RNA binding abilities of RBPs cause aberrant phase transitions. The intracellular environment is usually organized… Continue reading Prion-like RNA binding proteins (RBPs) such as for example TDP43 and