Background The definition of transcriptional networks through measurements of changes in

Background The definition of transcriptional networks through measurements of changes in gene expression profiles and mapping of transcription factor presenting sites is limited by the moderate overlap between presenting and gene expression changes and the inability to directly measure global nuclear transcription (coined transactome). established of transcriptionally controlled immediate c-Myc focus on genetics and pave… Continue reading Background The definition of transcriptional networks through measurements of changes in

During breast cancer tumor development the luminal space from the mammary

During breast cancer tumor development the luminal space from the mammary acinar device fills with proliferating epithelial cells that exhibit growth factor-independence cell attachment flaws and a far more invasive fibroblastic phenotype. proteins kinase cascade. Furthermore Cav-1-null mammary epithelial cells deprived of exogenous extracellular matrix underwent a spontaneous epithelial-mesenchymal changeover with reorganization from the actin… Continue reading During breast cancer tumor development the luminal space from the mammary