The discovery from the BRAFV600E mutation resulted in the introduction of

The discovery from the BRAFV600E mutation resulted in the introduction of vemurafenib (PLX4032), a selective BRAF inhibitor specific towards the kinase, for the treating metastatic melanomas. of development factors such as for example HGF and TGF-, this can result in intracellular signalling cascades. This review discusses the part MAPK and Phosphatidylinositol-3-kinase-protein kinase B-mammalian focus on… Continue reading The discovery from the BRAFV600E mutation resulted in the introduction of

Understanding the roles of human DNA repair proteins in genetic pathways

Understanding the roles of human DNA repair proteins in genetic pathways is a formidable challenge to many researchers. and pathways. We have developed a model yeast system to study LGD1069 the poorly defined genetic functions of the Werner syndrome helicase-nuclease (through its catalytic activities and protein interactions. The human gene and associated variants cloned into… Continue reading Understanding the roles of human DNA repair proteins in genetic pathways