BIIE0246, a newly synthesized non-peptide neuropeptide Y (NPY) Y2 receptor antagonist, could contend with high affinity (8 to 15?nM) for particular [125I]PYY3C36 binding sites in HEK293 cells transfected using the rat Con2 receptor cDNA, and in rat human brain and individual frontal cortex membrane homogenates. obstructed the contraction induced by PYY3C36, however, not that of… Continue reading BIIE0246, a newly synthesized non-peptide neuropeptide Y (NPY) Y2 receptor antagonist,